Patients and visitors to Norfolk's three main hospitals will no longer have to wear a face mask from Monday.
The Norfolk and Norwich University (N&N), Queen Elizabeth and James Paget University Hospital (JPUH) say the move follows discussions with the NHS Norfolk and Waveney Integrated Care System (ICS) and risk assessments.
The N&N said: "Instead of face masks being universally worn, they will be required in certain settings based on the local risk assessments.
"Staff will continue to wear masks when caring for patients who have a confirmed or suspected infectious respiratory illnesses and when caring for immunosuppressed patients.
"Patients and carers are not required to wear a face mask unless they have suspected or confirmed Covid-19 or another respiratory infection."
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The QEH said: "We are relaxing the requirement to wear a face mask for staff, patients, carers and visitors.
"Patients, carers and visitors are not required to wear a face mask unless they have suspected or confirmed Covid-19 or another respiratory infection."
The JPUH added: "In certain circumstances, our staff will continue to wear masks, such as when they are caring for patients who have a confirmed or suspected infectious respiratory illness and when caring for those who require protective isolation.
"We would ask that all visitors continue to practice good hand hygiene by washing their hands on arrival at the hospital."
Masks will still be available at all three hospitals for anyone who would like to wear one.
Prof Nancy Fontaine, chief nurse and director of infection control at the N&N, said: "We understand that after three years of mask wearing there will be some anxiety and we want to reassure staff, patients, carers and visitors that masks will still be available at our hospitals for those who wish to wear one."
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